基克尔（约翰·巴里摩尔 John Barrymore 饰）是一名知识非常渊博的科学家，他将毕生的经历都投注到了探索人性的善恶奥妙之中，并且最终制造出了一种可怕的药剂，这种药剂能够令基克尔化身成为海德先生，基克尔将自己所有的恶意和坏念头都投射到了海德的大脑里。白天，基克尔行医救人乐善好施，待到夜幕降临，海德先生便会现身，杀人害命，无恶不作。
　　基克尔有一位名叫伊芙（妮塔·纳尔迪 Nita Naldi 饰）的未婚妻，两人之间的感情非常的要好，然而，海德先生的存在让基克尔不自觉的被名叫碧翠丝的放荡妓女所吸引。分裂的人格让基克尔感到万分的痛苦，他想要消灭海德先生。

　　影片聚焦“无声末世”第一天，人类尚未掌握“出声即死”的法则，在怪物面前不堪一击。数以千计的怪物从天而降，怪物数量达到系列之最，视角也从前作的乡村小镇升级到美国第一大都市——纽约，全球沦陷，人类生活的街道、地铁、超市等地都变得危机四伏，一旦出声便会被潜藏的怪物“贴脸开大”，喧嚣的纽约沦陷为一座沉默的孤城，苟活的人类在此上演一场极限大逃亡。

　　A massive earthquake strikes the United States, which destroys the West Coast and unleashes a massive flood that threatens to destroy the East Coast as well.
　　If you__APOS__re wondering about this film and why it__APOS__s dubbed in Italian, then read the following comment from IMDb:
　　I have always wondered about the disappearance of __QUOTE__Deluge__QUOTE__. Why for so many years, seemingly since it__APOS__s release in 1933, this film vanished from the face of the earth. After seeing it, courtesy of the efforts of Mr. Wade Williams __AMPERSAND__ Co., I__APOS__m still puzzled, but I have a theory. In 1933, __QUOTE__the code__QUOTE__ was enacted that pretty much took care of sex and violence in Hollywood. While not an explicit film by any means, __QUOTE__Deluge__QUOTE__ does deal fairly frankly with sexuality, lust and rape. I wonder if RKO discovered they had a film that they could not re-release, much like the fabled lost Warner Bros. comedy __QUOTE__Convention City__QUOTE__. It__APOS__s a shame for, while it is a dated film, I find it quite unique and surprising for it__APOS__s era and a fairly successful attempt to create something different in an era when films were already becoming cookie cutter by-products of the studio machine (not that many of those cookies aren__APOS__t tasty, mind you). And even though the only available copy at this writing is dubbed into Italian, I don__APOS__t find that a hinderance. An excellent job was done in subtitling the film, and much of the film is visual anyway.